Blog Posts:
Sclerostin-inhibiting antibodies as an osteo-anabolic treatment
Osteoporosis is characterized by a decreased bone mass, leading to fragile bones more prone to fractures. This is caused by an imbalance in bone formation, when the bone-forming osteoblasts cannot catch up with the bone-resorbing osteoclasts. Previously, drugs used for the treatment of osteoporosis, such as bisphosphonates and denosumab, focused on inhibiting the bone resorption,…
Bone and muscle communicate upon exercise
Bone has long been thought of to be a static organ, providing mechanical support to the body. However, recently several discoveries have shown that bone could also act as an endocrine organ, in which it signals to other organs, influencing glucose metabolism, energy expenditure and male fertility (Karsenty, 2011). More specifically, signaling between the bone…
Osteoclast secreted proteins link to global energy metabolism
Bone is a very dynamic organ that undergoes constant remodeling throughout life: osteoclasts resorb the bone matrix whereas osteoblasts lay down a new layer of minerals. This process of bone remodeling is necessary to remove old bone matrix and repair stress-induced micro-cracks. This balance of bone resorption and formation is tightly regulated, as an imbalance…
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